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自分自身で記入する認知機能評価ツールは、どの程度正確に認知症を発見できるのだろうか?

5 months 2 weeks ago
自分自身で記入する認知機能評価ツールは、どの程度正確に認知症を発見できるのだろうか? 主な結果 - このエビデンスは、認知症の発見と診断に、自己記入式認知機能評価ツールを使用できることを示唆している。 - 一種類の評価ツールを他のものよりも推奨する十分なエビデンスはない。 - 診療所や家庭など、さまざまな環境におけるこれらの認知機能評価ツールの使用や、認知症を示すスコアについて、さらなる研究が必要である。 なぜ認知症の発見を改善することが重要なのか? 世界的に長寿化が進んでいるため、認知症と診断される人の数は今後大幅に増加すると予想されている。認知症の人が増えると、多大な医療や社会にかかわる費用をもたらすだろう。認知症は、日常生活に介助が必要になるまで記憶力が低下する永続的な症状である。正確で迅速な診断により、認知症の人やその家族は治療や支援を受けることができる。病態が存在するのに気づかなかった場合(偽陰性)、記憶、思考、行動を助ける治療を受けるのが遅れたり、ソーシャルワークや作業療法などの社会サービスからの支援を受けるのが遅れたりすることがある。認知症の誤った診断(偽陽性)は、検査を受けた人とその家族に精神的、心理的苦痛を与える可能性がある。現在、認知症の診断には専門のクリニックでの対面評価が必要であり、病歴、身体検査、血液検査、脳スキャンなどが検討される。 自己記入式認知機能...

Update on ‘Exercise therapy for chronic fatigue syndrome’

5 months 3 weeks ago

In 2019, Cochrane published an amended version of the review 'Exercise therapy for chronic fatigue syndrome’ and, at that time, announced an intention to further update the review. Due to insufficient new research in the field and a lack of resources to oversee this work, the update will not be proceeding.

Any feedback on this decision should follow Cochrane’s established complaints process. Any correspondence sent directly to individuals at Cochrane will not be considered.

Monday, December 16, 2024
Harry Dayantis

生徒の健康を向上させるための学校単位の方針と実践の改善

5 months 3 weeks ago
生徒の健康を向上させるための学校単位の方針と実践の改善 主な結果 - 学校やその職員は、支援する戦略が用いられた場合、生徒の健康的な食事、身体活動、肥満、タバコやアルコールの使用に対処するための介入をより適切に実施することができる。 - 学校とその職員がこうした介入策を実施するのを支援するためには、どの個別戦略が最適なのかを理解するために、さらなる研究が必要である。 - これまでの研究では、学校への実施支援による好ましくない影響は確認されておらず、その費用に関する情報も限られている。 知りたかったこと 5歳から18歳の生徒の食事、身体活動、肥満、タバコやアルコールの使用に対処するための学校単位の介入策の実施を支援するために、どのような戦略が有効であるかを知りたかった。例えば、学校食堂の運営者に対する教育や訓練(実施戦略)により、健康的でない食品の入手を減らし(実施結果)、生徒の食生活を改善するための健康的な食堂政策の実施(介入)を改善できるかどうか。また、費用対効果はあるのか、有害作用はないのか、などを知りたかった。その他の戦略の例としては、品質向上のための方法、学校の様子に関するフィードバック、注意書きや注意喚起、教育資源(マニュアルなど)などがある。 実施したこと 介入の実施を支援する戦略の使用したものとしていないものを比較した研究、あるいは2種類以上の異なる実施戦略を比較し...

£10 million global consortium to advance evidence synthesis in climate and health

6 months ago

Cochrane is part of a new global consortium to develop new tools, powered by artificial intelligence (AI), to analyse and synthesise research evidence on the relationships between climate change and human health.

The consortium is supported by a £10.2 million grant from Wellcome over four years, led by the Berlin-based climate research institute MCC.

The DESTINY project will develop novel AI-driven tools to make evidence synthesis faster, more efficient and continuously updated. The tools aim to automate and streamline tasks such as detecting relevant individual studies, extracting and synthesising their respective findings and identifying overarching insights.

As an internationally-recognised leader in evidence synthesis for human health, Cochrane will help to apply our methodological expertise to the field of climate research. We will co-lead several work programmes with the Campbell Collaboration, who specialize in evidence synthesis for social research.

It will be vital to ensure that outputs from automated tools are responsible and robust, with human oversight offering safeguards and methodological expertise. Cochrane will co-lead this workstream with Campbell, defining standards for responsible AI use and producing best-practice guidance. We will also help to ensure that the technology can be used equitably across the world, working with our extensive global network and consortium partners to build and strengthen capacity.

“Climate change poses one of the greatest threats to human health, so this project is both vital and timely,” says Dr Karla Soares-Weiser, Editor-in-Chief of the Cochrane Library and co-Principal Investigator on the DESTINY project. “It has the potential to transform evidence synthesis for climate and health, equipping decision-makers with the evidence they need to make informed decisions. Climate change is a key research priority in Cochrane’s scientific strategy, while methodological innovation is one of our core commitments. The DESTINY project will enable us to further these goals in collaboration with partners across the world, all bringing our own strengths to deliver the best outcomes.”

The project takes place in the context of a wider investment into evidence synthesis infrastructure, with £54.2 million of funding announced in September from both Wellcome and the UK government. The DESTINY grant is a separate award focused on climate change and health, signalling Wellcome’s leadership in this area.

“Stopping climate change is critical for securing human health,” says Jan Minx, head of the MCC working group Applied Sustainability Science and principal investigator of the DESTINY project. “Policymakers need the best and most recent scientific evidence to support their decisions, but the ready-to-hand evidence is often anecdotal and outdated. This project is pushing the boundaries of what is possible by using the latest advances in AI. It will demonstrate that the scientific knowledge needed for health-centred climate action can be synthesised and provided almost instantly. Speed and scientific rigour can go hand in hand – this is key to efficiently solving the big issues of our time.”

The consortium partners are Cochrane, University College London, The London School of Hygiene & Tropical Medicine, the ACRES Center for Rapid Evidence Synthesis, Future Evidence Foundation, the African Synthesis Centre for Climate Change, Environment and Development, Effective Basic Services (eBase) Africa, the Campbell Collaboration. “Having a diverse community of partners will ensure equity and inclusion in global evidence infrastructures,” says Patrick Okwen, Co-Investigator from eBase Africa.

Friday, December 6, 2024
Harry Dayantis

Cochrane seeks Assistant Quality Assurance Editor

6 months ago

Title: Assistant Quality Assurance Editor
Specifications: Permanent – Full Time
Salary: £30,000 per annum
Location: (Remote) based in the UK, Germany or Denmark
Directorate: Evidence Production and Methods Directorate
Closing date: 17 December 2024

Cochrane is an international charity. For 30 years we have responded to the challenge of making vast amounts of research evidence useful for informing decisions about health. We do this by synthesising research findings and our work has been recognised as the international gold standard for high quality, trusted information.

As Assistant Quality Assurance Editor within Cochrane’s Editorial Department, you will provide support to the Quality Assurance Editor and Senior Quality Assurance Editor, to help them to assess whether protocols, reviews and updates submitted to Cochrane’s Central Editorial Service have met Cochrane’s methodological standards. The post holder will provide this support by gathering information on individual reviews (e.g., by performing initial checks on submitted reviews, identifying and accessing relevant papers, or performing consistency checks within the reviews), assisting with the write up of peer review reports, and helping the Quality Assurance Team to reach consensus on recommendations to make for each submission.

You will also be trained to conduct your own full assessments of protocols, reviews and updates submitted to Cochrane’s Central Editorial Service have met Cochrane’s methodological standards, with the possibility of moving up a level to the role of ‘Quality Assurance Editor’ at a future stage. 

Don’t have every single qualification? We know that some people are less likely to apply for a job unless they are a perfect match. At Cochrane, we’re not looking for “perfect matches.” We’re looking to welcome people to our diverse, inclusive, and passionate workplace. So, if you’re excited about this role but don’t have every single qualification, we encourage you to apply anyway. Whether it’s this role or another one, you may be just the right candidate.

Our organisation is built on four core values:

Collaboration: Underpins everything we do, locally and globally.

Relevant: The right evidence at the right time in the right format.

Integrity: Independent and transparent.

Quality: Reviewing and improving what we do, maintaining rigour and trust.

You can expect:

  • An opportunity to truly impact health globally.
  •   A flexible work environment
  • A comprehensive onboarding experiences.
  •  An environment where people feel welcome, heard, and included, regardless of their differences.

Cochrane welcomes applications from a wide range of perspectives, experiences, locations, and backgrounds; diversity, equity and inclusion are key to our values.

How to apply

  •  For further information on the role and click “how to apply”.
  • The deadline to receive your application is 17 December, 2024.
  • The supporting statement should indicate why you are applying for the post, and how far you meet the requirements, using specific examples.
  • Read our Recruitment Privacy Statement
Thursday, December 5, 2024 Category: Jobs
Mia Parkinson

運動は変形性膝関節症に対する効果的な治療法か?

6 months ago
運動は変形性膝関節症に対する効果的な治療法か? 主なメッセージ - 運動は、アテンションコントロールグループ(研究担当者またはケア提供者との1回以上の関わりがあるグループ[訳注:健康教育や栄養指導など、痛みや機能等の結果に影響しない介入をうけた])やプラセボグループ[訳注:痛みや機能等の結果に影響しない介入を受けた]と比較した場合、痛みや身体機能の改善につながり、治療なしや通常のケア(かかりつけ医による日常的な治療など)、限定的な教育(基本的な情報が載ったパンフレットやオンライン情報へのリンクの提供など)と比較した場合、痛みや身体機能、生活の質(QOL)の改善につながる可能性がある。また、運動に別の治療を加えた場合も、その治療のみのときと比較して、痛み、身体機能、QOLの改善につながる可能性がある。しかし、その効果は臨床上重要かどうかは不明であり、患者にはっきりとした違いがわかるような症状の変化がない可能性があった。 - 研究数が多いにもかかわらず、多くの研究は参加者数が少なく、研究の質も低かった(参加者は自分がどの治療グループかどうかを知っていたなど)ため、結論に対する確実性が低かった。 運動は変形性膝関節症の人にどのように役に立つか? 変形性膝関節症は、持続的な痛みや能力が低下する原因となることが多い。運動は筋力を増加させ、関節の機能と可動域を改善することを目的としており、変...

筋力トレーニングはがんと診断された人の倦怠感に対する有効な療法であるか?

6 months 1 week ago
筋力トレーニングはがんと診断された人の倦怠感に対する有効な療法であるか? 要点 ‐がんの治療中に筋力トレーニングを行うと、倦怠感が軽減され、生活の質 (QOL)が向上する可能性がある。 ‐がんの治療後に筋力トレーニングを行うと、生活の質 (QOL)がやや向上するかもしれない。 ‐より多くの研究が行われれば、がんの治療前の筋力トレーニングの効果を理解するのに役立つだろう。 がん関連倦怠感とはなにか? がん関連倦怠感は、長期間続く極度の疲労感である。原因はがんそのもの、がんの治療、あるいはその両方である。がん関連倦怠感は身体と気分の両方に影響し、通常の活動を行うのが難しくなる。単なる疲労よりも強く、休んでも回復しない。 筋力トレーニングとは何か、またどのような効力を持つか? 筋力トレーニングとは、たとえばダンベル、トレーニングマシン、エクササイズバンド、あるいは自身の体重など、負荷をかけて筋肉を働かせるタイプの運動である。筋力トレーニングは、がん関連倦怠感に関係する多くの側面で作用する。たとえば、筋力を強化し、筋肉の減少を防ぎ、気分、睡眠、健康状態を改善する。このため、筋力トレーニングはがん関連倦怠感の緩和に役立つ可能性がある。 知りたかったこと 知りたかったのは、筋力トレーニングによってがん関連倦怠感が緩和されるかどうかである。倦怠感に対する何らかのプラスの効果がトレーニング終了後...

Cochrane seeks Consumer Support Officer (Remote/Flexible)

6 months 1 week ago

Title: Consumer Support Officer
Specifications: Fixed term contract (12 months) – Part time 0.6 FTE (22.5 hours)
Salary: £35,000 (pro-rata) per annum
Location: Remote working (UK office located in Central London)
Closing date: 11 December 2024
             
Cochrane is an international charity. For 30 years we have responded to the challenge of making vast amounts of research evidence useful for informing decisions about health. We do this by synthesising research findings and our work has been recognised as the international gold standard for high quality, trusted information.

Cochrane's strength is in its collaborative, global community. We have 110,000+ members and supporters around the world. Though we are spread out across the globe, our shared passion for health evidence unites us. Our Central Executive Team supports this work and is divided into four directorates: Evidence Production and Methods, Publishing and Technology, Development, and Finance and Corporate Services.

The Consumer Support Officer will work closely with Cochrane’s Consumer Engagement Manager to support the involvement of consumers (patients, carers and the public) in the Welcome-funded GALENOS project, including in systematic reviews about mental health topics. Support of consumers in this work will involve connecting consumers with lived experience of mental health challenges to researchers, developing learning resources to support consumer involvement in systematic reviews, and generally promoting patient and public involvement in the systematic review space.

Don’t have every single qualification? We know that some people are less likely to apply for a job unless they are a perfect match. At Cochrane, we’re not looking for “perfect matches.” We’re looking to welcome people to our diverse, inclusive, and passionate workplace. So, if you’re excited about this role but don’t have every single qualification, we encourage you to apply anyway. Whether it’s this role or another one, you may be just the right candidate.

Our organisation is built on four core values:

Collaboration: Underpins everything we do, locally and globally.

Relevant: The right evidence at the right time in the right format.

Integrity: Independent and transparent.

Quality: Reviewing and improving what we do, maintaining rigour and trust.

 

You can expect:

  • An opportunity to truly impact health globally.
  •   A flexible work environment
  • A comprehensive onboarding experiences.
  •  An environment where people feel welcome, heard, and included, regardless of their differences.

Cochrane welcomes applications from a wide range of perspectives, experiences, locations, and backgrounds; diversity, equity and inclusion are key to our values.

 

How to apply

  •  For further information on the role and click “how to apply”.
  • The deadline to receive your application is 11 December, 2024.
  • The supporting statement should indicate why you are applying for the post, and how far you meet the requirements, using specific examples.
  • Read our Recruitment Privacy Statement

 

 

Wednesday, November 27, 2024 Category: Jobs
Mia Parkinson

Cochrane seeks Business Development Manager (Remote/Flexible)

6 months 1 week ago

Title: Business Development Manager
Specifications: Permanent – Full time
Salary: £45,000 per annum
Location: Remote working (UK office located in Central London)
Closing date:  3 January 2025

Cochrane is an international charity. For 30 years we have responded to the challenge of making vast amounts of research evidence useful for informing decisions about health. We do this by synthesising research findings and our work has been recognised as the international gold standard for high quality, trusted information.

Cochrane has ambitious plans to raise funds to support our work to address the world’s most pressing health challenges. This role will work closely with the Head of Business Development to implement a strategic fundraising plan to make those ambitions a reality. 

We are seeking a self-starter; an experienced and energetic fundraiser with a proven track-record of successfully securing five and six figure gifts from a wide range of donors. You have experience of fundraising from global high-value trusts and foundations, as well as from government or multilateral donors (e.g. the European Union).   

You are an experienced donor account manager with excellent communication skills. You will promote best practice within your field of expertise and will work to ensure the highest quality and levels of efficiency. You are aligned with Cochrane’s core mission and vision, and you will be comfortable brokering relationships with representatives from key donors. 

Don’t have every single qualification? We know that some people are less likely to apply for a job unless they are a perfect match. At Cochrane, we’re not looking for “perfect matches.” We’re looking to welcome people to our diverse, inclusive, and passionate workplace. So, if you’re excited about this role but don’t have every single qualification, we encourage you to apply anyway. Whether it’s this role or another one, you may be just the right candidate.

Our organisation is built on four core values:

Collaboration: Underpins everything we do, locally and globally.

Relevant: The right evidence at the right time in the right format.

Integrity: Independent and transparent.

Quality: Reviewing and improving what we do, maintaining rigour and trust.

You can expect:

  • An opportunity to truly impact health globally.
  •   A flexible work environment
  • A comprehensive onboarding experiences.
  •  An environment where people feel welcome, heard, and included, regardless of their differences.

Cochrane welcomes applications from a wide range of perspectives, experiences, locations, and backgrounds; diversity, equity and inclusion are key to our values.

How to apply

  •  For further information on the role and click “how to apply”.
  • The deadline to receive your application is 3 January, 2025.
  • The supporting statement should indicate why you are applying for the post, and how far you meet the requirements, using specific examples.
  • Read our Recruitment Privacy Statement

 

 

Wednesday, November 27, 2024 Category: Jobs
Mia Parkinson

臨床試験の結果が公表されるまでの期間は?

6 months 1 week ago
臨床試験の結果が公表されるまでの期間は? このレビューはどのような疑問を解決するのか? 健康介入を検討するために実施された臨床試験(研究)のうち、ジャーナルに掲載されたものはどれくらいあるのか。論文発表率や論文発表までの期間は、試験結果の性質、参加者や試験施設の数、あるいは試験の資金源に影響されるのか。 主な結果 全臨床試験の半数近く(47%)が未発表のままである。 臨床試験が公表されるかどうか、またどのくらいの期間を要するかは、肯定的な結果が得られたかどうか、臨床試験の規模、単施設か多施設か、どのような組織が資金を提供したか、などに影響される。 出版と出版バイアスとは何か? 臨床試験結果の公表にはいくつかの段階がある。このプロセスは、臨床試験が実施されることから始まり、その後、試験の目的、方法、結果を記載した要約文書(原稿)が作成される。原稿はジャーナル編集者に送られ、編集者や同僚、そして原稿のテーマに関する専門家であるが、試験には関与していない査読者によってチェックされ、コメントされる。原稿が正しく適切であると評価されれば、オンラインまたは印刷されたジャーナルに掲載され、研究結果に関心を持つ人々に読まれることになる。原稿にアクセスするには購読料が必要な場合もあるが、多くの場合は「オープンアクセス」、つまり自由に利用できる。試験結果を公表するかどうかの決定が、その結果の性質、す...